Cytotoxic activities of some novel benzhydrylpiperazine derivatives

Gurdal E., Yarim M., Durmaz I., Cetin-Atalay R.

Drug Research, cilt.63, sa.3, ss.121-128, 2013 (Scopus) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 63 Sayı: 3
  • Basım Tarihi: 2013
  • Doi Numarası: 10.1055/s-0032-1333275
  • Dergi Adı: Drug Research
  • Derginin Tarandığı İndeksler: Scopus
  • Sayfa Sayıları: ss.121-128
  • Anahtar Kelimeler: benzhydrylpiperazine, benzoyl chloride, cytotoxicity, sulfonyl chloride, sulphorhodamine B
  • İstanbul Medipol Üniversitesi Adresli: Hayır

Özet

This study presents the synthesis of nineteen 1-(substitutedbenzoyl)-4- benzhydrylpiperazine and 1-[(substitutedphenyl)sulfonyl]-4-benzhydrylpiperazine derivatives. In vitro cytotoxic activities of the compounds were screened against hepatocellular (HUH-7), breast (MCF-7) and colorectal (HCT-116) cancer cell lines by sulphorhodamine B assay. Among the test compounds, benzamide derivatives had high cytotoxic activity whereas sulfonamide derivatives showed variable 50% growth inhibition (GI50). © Georg Thieme Verlag KG Stuttgart · New York.