Cytotoxic activities of some novel benzhydrylpiperazine derivatives

Gurdal E., Yarim M., Durmaz I., Cetin-Atalay R.

Drug Research, vol.63, no.3, pp.121-128, 2013 (Scopus) identifier identifier

  • Publication Type: Article / Article
  • Volume: 63 Issue: 3
  • Publication Date: 2013
  • Doi Number: 10.1055/s-0032-1333275
  • Journal Name: Drug Research
  • Journal Indexes: Scopus
  • Page Numbers: pp.121-128
  • Keywords: benzhydrylpiperazine, benzoyl chloride, cytotoxicity, sulfonyl chloride, sulphorhodamine B
  • Istanbul Medipol University Affiliated: No

Abstract

This study presents the synthesis of nineteen 1-(substitutedbenzoyl)-4- benzhydrylpiperazine and 1-[(substitutedphenyl)sulfonyl]-4-benzhydrylpiperazine derivatives. In vitro cytotoxic activities of the compounds were screened against hepatocellular (HUH-7), breast (MCF-7) and colorectal (HCT-116) cancer cell lines by sulphorhodamine B assay. Among the test compounds, benzamide derivatives had high cytotoxic activity whereas sulfonamide derivatives showed variable 50% growth inhibition (GI50). © Georg Thieme Verlag KG Stuttgart · New York.