Cytotoxic activity of the root and fruit extracts of Heptaptera anisoptera (DC.) Tutin


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TOSUN F., MİSKİ M.

Acta Pharmaceutica Sciencia, vol.58, no.1, pp.21-25, 2020 (Scopus) identifier

  • Publication Type: Article / Article
  • Volume: 58 Issue: 1
  • Publication Date: 2020
  • Doi Number: 10.23893/1307-2080.aps.05801
  • Journal Name: Acta Pharmaceutica Sciencia
  • Journal Indexes: Scopus, EMBASE
  • Page Numbers: pp.21-25
  • Keywords: Apiaceae, Cytotoxic activity, Heptaptera anisoptera
  • Istanbul Medipol University Affiliated: Yes

Abstract

Cytotoxic activities of the root and fruit extracts of Heptaptera anisoptera (DC.) Tutin were investigated on the colon cancer COLO205 and KM12 cell lines. The dichloromethane extract of the roots of H. anisoptera showed cytotoxic activity with IC50 values of 3.1 and 3.9 ug/mL on the COLO205 and KM12 cell lines, respectively. Cytotoxic activity of the dichloromethane extract of the fruits were similar to those of root extract with IC50 values of 5.5 and 4.8 ug/mL on the COLO205 and KM12 cell lines, respectively.