Serum and Aqueous Concentrations of Inflammatory Markers in Diabetic Macular Edema

KOCABORA M. S., Telli M. E., Fazil K., Erdur S. K., ÖZSÜTÇÜ M., Cekic O., ...More

Ocular Immunology and Inflammation, vol.24, no.5, pp.549-554, 2016 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 24 Issue: 5
  • Publication Date: 2016
  • Doi Number: 10.3109/09273948.2015.1034804
  • Journal Name: Ocular Immunology and Inflammation
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.549-554
  • Keywords: C-reactive protein, diabetic retinopathy, inflammation, macular edema, tumor necrosis factor-alpha
  • Istanbul Medipol University Affiliated: Yes


Purpose: To investigate the relationship between the serum and aqueous levels of inflammatory markers and diabetic macular edema (DME). Methods: The study included four patient groups: the healthy control group (n = 23 eyes); the diabetic control group (n = 22 eyes); the groups with and without DME (n = 20 eyes and n = 22 eyes, respectively). The patients were evaluated based on their serum levels of HbA1c, C-reactive protein (CRP) and serum and aqueous levels of tumor necrosis factor-alpha (TNF-α). Results: Statistically significant differences were present for the serum CRP levels and for the aqueous TNF-α levels between the healthy control group and the group with DME (p = 0.004 and p = 0.03, respectively); for the serum TNF-α levels between the healthy control group and the groups without and with DME (p = 0.009 and p = 0.001, respectively). Conclusions: Increased serum levels of CRP and serum and aqueous levels of TNF-α in DME suggest that inflammation is involved in the pathogenesis of DME.