Synthesis and antimicrobial activity evaluation of some new adamantane derivatives

Çaliş Ü., Yarim M., Köksal M., Özalp M.

Arzneimittel-Forschung/Drug Research, cilt.52, sa.10, ss.778-781, 2002 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 52 Sayı: 10
  • Basım Tarihi: 2002
  • Doi Numarası: 10.1055/s-0031-1299966
  • Dergi Adı: Arzneimittel-Forschung/Drug Research
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.778-781
  • Anahtar Kelimeler: Adamantane derivatives, Antibacterial activity, Antifungal activity, In vitro studies, Schiff bases, Synthesis
  • İstanbul Medipol Üniversitesi Adresli: Hayır

Özet

In this study, some new Schiff bases were synthesized as antimicrobial agents using benzaldehyde derivatives and 1- or 2-aminoadamantane. The structures of the synthesized compounds were confirmed by IR, 1H-NMR and elementary analysis. Antimicrobial activities of the synthesized compounds were tested against some bacteria and yeast-like fungi. The antimicrobial activity of the compounds was investigated by broth microdilution method using two Gram positive (Staphylococcus aureus ATCC 25923, Enterococcusfaecalis ATCC 29212) and two Gram negative (Escherichia coli ATCC 25922, Pseudomonas aeruginosa ATCC 27853) bacteria and yeast-like fungi (Candida albicans ATCC 90028, Candida krusei ATCC 6258, Candida parapsilosis ATCC 22019). The antifungal activity of 1-((2-chloro-3,4-dimethoxybenzylidene) amino (adamantane (compound 3) against C. krusei and C. parapsilosis (minimal inhibitory concentration 32 μg/ml) was higher than that of the other tested compounds.