Gas chromatographic determination of quinolizidine alkaloids in Genista sandrasica and their antimicrobial activity

Küçükboyaci N., Özkan S., TOSUN F.

Records of Natural Products, cilt.6, sa.1, ss.71-74, 2012 (SCI-Expanded) identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 6 Sayı: 1
  • Basım Tarihi: 2012
  • Dergi Adı: Records of Natural Products
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.71-74
  • Anahtar Kelimeler: Alkaloids, Antimicrobial activity, Fabaceae, GC-MS, Genista sandrasica
  • İstanbul Medipol Üniversitesi Adresli: Hayır

Özet

Alkaloid profile of the aerial parts of Genista sandrasica Hartvig & Strid. (Fabaceae) growing in Turkey was studied by capillary gas chromatography-mass spectrometry (GC-MS). Ten quinolizidine alkaloids were identified in the alkaloid extract of G. sandrasica. The main alkaloids were: sparteine (13.68%), N-acetylcytisine (6.48%), 13-methoxylupanine (13.12%), anagyrine (40.49%) and baptifoline (10.76%). In addition, antibacterial and antifungal activities of the alkaloid extract of G. sandrasica were tested against standard strains of the bacteria (Escherichia coli, Pseudomonas aeruginosa, Bacillus subtilis and Staphylococcus aureus) as well as the fungi (Candida albicans and Candida krusei). The alkaloid extract of G. sandrasica showed significant activity against B. subtilis and S. aureus with minimum inhibitory concentrations (MIC) of 31.25 and 62.5 μg/mL. © Published 08/05/2011 EISSN: 1307-6167.