Effect of Boron on Sympathetic Skin Response in Rats

Boyuk G., Dolu N., Aksoy B.

INDIAN JOURNAL OF DERMATOLOGY, vol.68, no.6, pp.723-730, 2023 (SCI-Expanded)

  • Publication Type: Article / Article
  • Volume: 68 Issue: 6
  • Publication Date: 2023
  • Doi Number: 10.4103/ijd.ijd_7_22
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, CAB Abstracts, CINAHL, EMBASE, Veterinary Science Database, Directory of Open Access Journals
  • Page Numbers: pp.723-730
  • Istanbul Medipol University Affiliated: Yes



Boron effects on reproduction and growth have been extensively studied in animals. Electrodermal activity (EDA) reflects the activity of eccrine sweat glands stimulated by the release of acetylcholine from sympathetic nerves.


In the presen study, it was aimed to examine the effect of boron, which was turned into cream, on sweat glands.


A cream form mixed with thyme oil was prepared for EDA recording. Our groups were formed as EDA recording gel (Group 1), cream with thyme oil (Group 2), cream containing 10% boron (Group 3) and cream containing 30% boron (Group 4). In each group, 3 months old, 10 male rats were used, and creams were applied to the soles of the hind extremities of the rats, EDA was recorded from this region after half an hour, and skin conductivity levels (SCL) were recorded as tonic (at rest) and phasic (with auditory sound stimulation).


EDA results recorded in the morning were analysed with tonic and phasic recordings. In the morning SCL measurements, tonic SCL value of Group 4 was higher than the other groups (P < 0.001). Although the phasic SCL value was measured, it was significantly higher in Group 4 than in all groups (P < 0.0s).


EDA measurements showed that boron increased sweat gland activity by increasing sympathetic nerve activity.