Purpose: The purpose of this paper is to analyze the relationship of the organization and whether employees in the companies operating in the textile sector receive leadership support when they experience depression. Design/methodology/approach: Data were obtained from personnel working in textile companies in organized industrial zones located within five provinces: Istanbul, Ankara, Bursa, Izmir and Antalya (defined as industrial cities of Turkey). The reason for choosing these companies was related to the question of whether the mental state of the personnel may have had an impact on the success of the company, especially as the textile industry works with more manpower and knowledge due to the nature of the job. The moderation relationship of leadership support to the relationship of this situation on organizational culture and organizational commitment was analyzed using the SmartPLS program. Findings: As a result of the analyzes, it was determined that the depression of the employees weakens the organizational commitment, thereby leading to a negative relationship within the organizational culture. But, with leadership support, the organizational commitment increases and the organizational culture is positively affected. Research limitations/implications: As the research was conducted in companies in the textile sector in Istanbul, this limitation should be taken into account in future research. In addition, as data is collected from white-collar employees in the administrative staff position (the sample group), this situation should also be taken into account. Considering the questions asked in the questionnaire, it is recommended that future research be conducted on blue-collar workers. Practical implications: It can be concluded that the leadership role is an important factor for organizations to prevent employees from being depressed and employees should receive positive support to ensure organizational commitment. At the same time, it can be concluded that the organizational culture is positively affected if the depression of the employees has decreased. Originality/value: The research is an original study in terms of investigating the relationship of depression status to the leadership support of employees working in textile companies in an environment where competition is consistently intense.