Potent colon cancer cell line toxicity of the fruit extracts of Heptaptera triquetra (Vent.) Tutin

Creative Commons License

TOSUN F., MİSKİ M.

Acta Pharmaceutica Sciencia, vol.60, no.3, pp.295-299, 2022 (Scopus) identifier

  • Publication Type: Article / Article
  • Volume: 60 Issue: 3
  • Publication Date: 2022
  • Doi Number: 10.23893/1307-2080.aps.6019
  • Journal Name: Acta Pharmaceutica Sciencia
  • Journal Indexes: Scopus, EMBASE
  • Page Numbers: pp.295-299
  • Keywords: Apiaceae, Cytotoxic activity, Heptaptera triquetra
  • Istanbul Medipol University Affiliated: Yes

Abstract

Cytotoxic activities of the fruit extracts of Heptaptera triquetra (Vent.) Tutin were investigated on the colon cancer COLO205 and KM12 cell lines. The dichloromethane extract of the fruits of H. triquetra showed the highest cytotoxic activities with IC50 values of 9.3 and 5.3 ug/mL on the COLO205 and KM12 cell lines, respectively. Whereas, the ethyl acetate extract of the fruits showed moderate cytotoxic activity with IC50 values of 22.3 ug/mL against the KM12 cell lines.