Decreased Salivary Gremlin-1 Levels in Periodontitis Patients
International Archives of Dental Sciences, cilt.46, sa.1, ss.1-7, 2025 (TRDizin)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 46 Sayı: 1
- Basım Tarihi: 2025
- Dergi Adı: International Archives of Dental Sciences
- Derginin Tarandığı İndeksler: TR DİZİN (ULAKBİM)
- Sayfa Sayıları: ss.1-7
- Açık Arşiv Koleksiyonu: AVESİS Açık Erişim Koleksiyonu
- İstanbul Medipol Üniversitesi Adresli: Evet
Özet
Morphogenetic Proteins involved in processes such as angiogenesis, inflammation, fibrosis, and osteogenesis. The aim of this study is to compare salivary Gremlin-1 levels in individuals with periodontitis to those in periodontally healthy individuals and to evaluate the relationship of these levels with clinical parameters.
METHODS: A total of 40 systemically healthy individuals were included, comprising 20 stage III/grade B periodontitis and 20 periodontal healthy individuals. Clinical periodontal parameters (plaque index (PI), probing depth (PD), clinical attachment loss (CAL) and bleeding on probing (BOP)) were recorded. Salivary Gremlin-1 levels were analyzed using an ELISA.
RESULTS: All periodontal measurements were significantly higher in the periodontitis group rather than controls (p<0.0001). Salivary Gremlin-1 levels were significantly lower in the periodontitis compared to the control group (p<0.0001). Negative correlations were found between Gremlin-1 levels and PI (r=-0.592, p=0.011), PD (r=-0.452, p=0.003), and CAL (r=-0.453, p=0.003). No significant correlation was observed between Gremlin-1 levels and BOP (p>0.05).
CONCLUSION: Decreased saliva Gremlin-1 levels in periodontitis patients and their negative correlation with clinical periodontal parameters suggest that saliva Gremlin-1 might modulate the inflammation and limit tissue remodeling as a systemic compensation mechanism in periodontitis.