Akademik Veri Yönetim Sistemi
Natural Products in Drug Discovery and Human Health (NatProdDDH), Lisbon, Portekiz, 28 - 31 Temmuz 2019, ss.153
The genus Malabaila Hoffm. (Apiaceae) is represented by seven species in Turkey [1]. Malabaila species have been used for stomach disorders, intestinal parasites, haemorrhoids, nail disorders in Turkish folk medicine [2]. A literature survey reveal that the genus Malabaila extracts have antioxidant and antimicrobial activities [3, 4]. Air-dried and powdered plant material extracted with dichloromethane and methanol in Soxhlet apparatus respectively. Hydrodistilled fruit essential oil from M. secacul was analysed by GC-FID and GC-MS systems, simultaneously. The main compounds were determined as hexyl butyrate (73.0%) and hexyl octanoate (16.5%). 29 components were identified representing 98.3% of the
total oil. The anticandidal and antibacterial activities of the extracts and the essential oil were determined by using micro broth dilution methods with standard antimicrobial agents [5, 6] against 12 pathogenic Candida and bacteria strains. The fruit oil showed growth inhibition between the concentrations of 0.25-1.5 mg/mL against tested microorganisms, where the methanol and dichloromethane extracts of the fruits showed activity at the ranges of 0.15-5.0 and 0.15-10.0 mg/mL, respectively. The root extracts demonstrated moderate to good effects at the concentrations of 0.03 to 5 mg/mL.
Remarkably, Candida tropicalis was inhibited by the dichloromethane extracts at the concentration
of 0.039 mg/mL.