Therapeutic effects of vitamin D on acetic acid-induced colitis in rats


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BADEMCİ R., Erdoğan M. A., Kara A. Y., Yiğittürk G., Erbaş O.

Acta Cirurgica Brasileira, vol.35, no.4, pp.1-8, 2020 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 35 Issue: 4
  • Publication Date: 2020
  • Doi Number: 10.1590/s0102-865020200040000004
  • Journal Name: Acta Cirurgica Brasileira
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, CAB Abstracts, EMBASE, MEDLINE, Veterinary Science Database, Directory of Open Access Journals
  • Page Numbers: pp.1-8
  • Keywords: Calcitriol, Colitis, Tumor Necrosis Factor-alpha, Malondialdehyde, Rats
  • Istanbul Medipol University Affiliated: Yes

Abstract

Purpose: To analyze the effect of calcitriol treatment on acute colitis in an experimental rat model. Methods: A total of 24 adult Sprague Dawley albino rats were randomly separated into 3 equal groups: control group (n:8), colitis group (n:8), calcitriol administered group (n:8). A single dose of acetic acid (1 ml of 4% solution) was administered intrarectally to induce colitis. Group 1 was given 1 ml/kg 0.9% NaCl intraperitoneally; rats belonging to Group 2 were administered calcitriol 1 µg/kg for 5 days. Results: Plasma tumor necrosis factor alpha, Pentraxin 3, and malondialdehyde levels were significantly lower in the calcitriol administered colitis group than in the standard colitis group (p<0.01). In the Calcitriol group, there was a significant histological improvement in hyperemia, hemorrhage and necrotic areas in the epithelium compared to the placebo group (p <0.000). Conclusion: The findings suggest that calcitriol may be an agent that could be used in acute colitis treatment.