Typhoid fever as a rare cause of hepatic, splenic, and bone marrow granulomas

Mert A., Tabak F., Ozaras R., ÖZTÜRK R., AKI S. H., Aktuglu Y.

Internal Medicine, vol.43, no.5, pp.436-439, 2004 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 43 Issue: 5
  • Publication Date: 2004
  • Doi Number: 10.2169/internalmedicine.43.436
  • Journal Name: Internal Medicine
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.436-439
  • Keywords: typhoid fever, granuloma, liver, spleen, bone marrow
  • Istanbul Medipol University Affiliated: Yes


During the course of typhoid fever, the usual histologic finding of the liver is "nonspecific reactive hepatitis." Hepatic granuloma (HG) is a rare complication of typhoid fever. We present two cases of typhoid fever with HG and review the relevant literature. Case 1 (a 53-year-old female) was found to have both hepatic and splenic granulomas. This is the first case of typhoid fever with splenic granulomas in the English language literature. Case 2 (a 66-year-old male) developed granulomas in the bone marrow in addition to HG. It should be considered that typhoid fever may lead to granulomas in several organs.