Synthesis and potent antimicrobial activity of some novel 4-(5,6-dichloro-7H-benzimidazol-2-yl)-N-substituted benzamides

ÖZDEN M. S., KARATAŞ BRISTOW H., YILDIZ S., GÖKER A. H.

Archiv der Pharmazie, vol.337, no.10, pp.556-562, 2004 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 337 Issue: 10
  • Publication Date: 2004
  • Doi Number: 10.1002/ardp.200400884
  • Journal Name: Archiv der Pharmazie
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.556-562
  • Keywords: H-benzimidazole, benzamide, antifungal and antibacterial activity, Turkey methicillin-resistant staphylococcus aureus, methicillin-resistant staphylococcus, epidermidis
  • Istanbul Medipol University Affiliated: Yes

Abstract

A series of 4-(5,6-dichloro-1H-benzimidazol-2-yl)-N-substituted benzamides were synthesized and evaluated for antibacterial and antifungal activities against Staphylococcus aureus, methicillin-resistant S. aureus (MRSA), methicillin-resistant S. epidermis (MRSE), Enterococcus faecalis, Escherichia coli and Candida albicans. Certain compounds inhibit bacterial growth with low MIC values (μg/mL). Among them, compounds 10 and 11 exhibited the greatest anti-bacterial activity with MIC values of 3.12 μg/mL against S. aureus, MRSA and MRSE.