The Use of Breast Magnetic Resonance Imaging Parameters to Identify Possible Signaling Pathways of a Serum Biomarker, HE4

Durur-Karakaya A., Durur-Subasi I., KARAMAN A., AKÇAY M. N., YÜCELİK Ş. S., Erdemci B., ...More

JOURNAL OF COMPUTER ASSISTED TOMOGRAPHY, vol.40, no.3, pp.436-441, 2016 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 40 Issue: 3
  • Publication Date: 2016
  • Doi Number: 10.1097/rct.0000000000000390
  • Journal Name: JOURNAL OF COMPUTER ASSISTED TOMOGRAPHY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.436-441
  • Keywords: breast cancer, HE4, magnetic resonance imaging
  • Istanbul Medipol University Affiliated: Yes

Abstract

Objectives: This study aimed to investigate the relationship between breast magnetic resonance imaging (MRI) parameters; clinical features such as age, tumor diameter, N, T, and TNM stages; and serum human epididymis protein 4 (HE4) levels in patients with breast carcinoma and use this as a means of estimating possible signaling pathways of the biomarker, HE4. Methods: Thirty-seven patients with breast cancer were evaluated by breastMRI and serum HE4 levels before therapy. Correlations between parameters including age, tumor diameter T and N, dynamic curve type, enhancement ratio (ER), slope washin (S-WI), time to peak (TTP), slope washout (S-WO), and the serum level of HE4 were investigated statistically. Human epididymis protein 4 levels of early and advanced stage of disease were also compared statistically. Results: Breast MRI parameters showed correlation to serum HE4 levels and correlations were statistically significant. Of these MRI parameters, S-WI had higher correlation coefficient than the others. Human epididymis protein 4 levels were not statistically different in early and advanced stage of disease. Conclusions: High correlation with MRI parameters related to neoangiogenesis may indicate signaling pathway of HE4.