Pharmaceutical applications of a nanospectroscopic technique: Surface-enhanced Raman spectroscopy

Yilmaz H., Yilmaz D., Taskin I. C., Culha M.

Advanced Drug Delivery Reviews, vol.184, 2022 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Review
  • Volume: 184
  • Publication Date: 2022
  • Doi Number: 10.1016/j.addr.2022.114184
  • Journal Name: Advanced Drug Delivery Reviews
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, Aerospace Database, Biotechnology Research Abstracts, Chemical Abstracts Core, Communication Abstracts, Compendex, EMBASE, International Pharmaceutical Abstracts, MEDLINE, Metadex, Civil Engineering Abstracts
  • Keywords: Surface-enhanced Raman Spectroscopy (SERS), Pharmaceuticals, Drug Discover, Detection, Drug Delivery, Biomedical Imaging, Drug Stability, Nanospectroscopy
  • Istanbul Medipol University Affiliated: Yes


Surface-enhanced Raman spectroscopy (SERS) is a very sensitive technique offering unique opportunities for detection and identification of molecules and molecular structures at extremely low concentrations even in complex sample matrixes. Since a nanostructured noble metal surface is required for the enhancement of Raman scattering, the acquired spectral information naturally originates from nanometer size domains making it a nanospectroscopic technique by breaking the diffraction limit of light. In this review, first Raman spectroscopy, its comparison to other related techniques, its modes and instrumentation are briefly introduced. Then, the SERS mechanism, substrates and the parameters influencing a SERS experiment are discussed. Finally, its applications in pharmaceuticals including drug discovery, drug metabolism, multifunctional chemo-photothermal-therapy-delivery-release-imaging, drug stability and drug/metabolite detection in complex biological samples are summarized and elaborated.