The therapeutic role of minocycline in Parkinson's disease


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Cankaya S., Cankaya B., Kilic U., Kilic E., Yulug B.

Drugs in Context, vol.8, 2019 (Scopus) identifier identifier

  • Publication Type: Article / Review
  • Volume: 8
  • Publication Date: 2019
  • Doi Number: 10.7573/dic.212553
  • Journal Name: Drugs in Context
  • Journal Indexes: Scopus
  • Keywords: Minocycline, Neurodegeneration, Neuroprotection, Parkinson's disease
  • Istanbul Medipol University Affiliated: Yes

Abstract

Minocycline, a semisynthetic tetracycline-derived antibiotic, has been shown to exert anti-apoptotic, anti-inflammatory, and antioxidant effects. Furthermore, there is rapidly growing evidence suggesting that minocycline may have some neuroprotective activity in various experimental models such as cerebral ischemia, traumatic brain injury, amyotrophic lateral sclerosis, Parkinson's disease (PD), Huntington's disease, and multiple sclerosis. In this perspective review, we summarize the preclinical and clinical findings suggesting the neuroprotective role of minocycline in PD.