How to create an experimental diabetes mellitus model?

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Köprülü R. E. P.

Pharmacia, vol.70, no.1, pp.105-111, 2023 (ESCI) identifier

  • Publication Type: Article / Article
  • Volume: 70 Issue: 1
  • Publication Date: 2023
  • Doi Number: 10.3897/pharmacia.70.e96028
  • Journal Name: Pharmacia
  • Journal Indexes: Emerging Sources Citation Index (ESCI), Scopus, Central & Eastern European Academic Source (CEEAS), EMBASE, Directory of Open Access Journals
  • Page Numbers: pp.105-111
  • Keywords: alloxan, experimental diabetes, method, streptozocin
  • Istanbul Medipol University Affiliated: Yes


Diabetes is a metabolic disorder characterized by chronic hyperglycemia. Early treatment is very important in terms of preventing diabetes-related late complications with high treatment costs and increasing the patient’s quality of life. In addition to investigating the pathophysiology of the disease studied, animal experiments pave the way for new approaches in treatments. Although there are many methods that can be used when creating a diabetes model, induction of diabetes with alloxan and streptozotocin are the most preferred ones. The aim of this article is to review the available information on diabetes-related methods, common problems and solutions, with known mechanisms of action, dose and time-determined methods.