Molecular Mechanisms of Early and Late LTP

Baltaci S. B., Mogulkoc R., Baltaci A. K.

Neurochemical Research, cilt.44, sa.2, ss.281-296, 2019 (SCI-Expanded, Scopus) identifier identifier

  • Yayın Türü: Makale / Derleme
  • Cilt numarası: 44 Sayı: 2
  • Basım Tarihi: 2019
  • Doi Numarası: 10.1007/s11064-018-2695-4
  • Dergi Adı: Neurochemical Research
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.281-296
  • Anahtar Kelimeler: Cpeb, Functional prions, Learning and memory, Ltp, Pkm zeta, Synaptic plasticity
  • İstanbul Medipol Üniversitesi Adresli: Hayır

Özet

LTP is the most intensively studied cellular model of the memory and generally divided at least two distinct phases as early and late. E-LTP requires activation of CaMKII that initiates biochemical events and trafficking of proteins, which eventually potentiate synaptic transmission, and is independent of de novo protein synthesis. In contrast, L-LTP requires gene expression and local protein synthesis regulated via TrkB receptor- and functional prions CPEB2-3-mediated translation. Maintenance of LTP for longer periods depends on constitutively active PKMζ. Throughout this review, current knowledge about early and late phases of LTP will be reviewed.