Molecular Mechanisms of Early and Late LTP

Baltaci S. B., Mogulkoc R., Baltaci A. K.

Neurochemical Research, vol.44, no.2, pp.281-296, 2019 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Review
  • Volume: 44 Issue: 2
  • Publication Date: 2019
  • Doi Number: 10.1007/s11064-018-2695-4
  • Journal Name: Neurochemical Research
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.281-296
  • Keywords: Cpeb, Functional prions, Learning and memory, Ltp, Pkm zeta, Synaptic plasticity
  • Istanbul Medipol University Affiliated: No

Abstract

LTP is the most intensively studied cellular model of the memory and generally divided at least two distinct phases as early and late. E-LTP requires activation of CaMKII that initiates biochemical events and trafficking of proteins, which eventually potentiate synaptic transmission, and is independent of de novo protein synthesis. In contrast, L-LTP requires gene expression and local protein synthesis regulated via TrkB receptor- and functional prions CPEB2-3-mediated translation. Maintenance of LTP for longer periods depends on constitutively active PKMζ. Throughout this review, current knowledge about early and late phases of LTP will be reviewed.