The axon protective effects of syringic acid on ischemia/reperfusion injury in a rat sciatic nerve model

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Tokmak M., Sehitoglu M. H., Yuksel Y., Guven M., AKMAN T., Aras A. B., ...More

Turkish Neurosurgery, vol.27, no.1, pp.124-132, 2017 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 27 Issue: 1
  • Publication Date: 2017
  • Doi Number: 10.5137/1019-5149.jtn.14656-15.5
  • Journal Name: Turkish Neurosurgery
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
  • Page Numbers: pp.124-132
  • Keywords: Axon, Sciatic nerve, Syringic acid, Methylprednisolone, Reperfusion, Malondialdehyde, Nuclear respiratory factor 1, Superoxide dismutase
  • Istanbul Medipol University Affiliated: Yes


Aim: In the relevant literature, there is no experimental study that investigated the axon protective effects of syringic acid- a polyphenol compound- with an anti-oxidant capacity on ischemia/reperfusion injury. Material and Methods: The rats were randomly divided into four groups: Control group (no medication or surgical procedure), Sham group, Syringic acid group, and Methyprednisolone (MP) Group. Ischemia was achieved by abdominal aorta clamping and all animals were sacrificed 24 hours after ischemia. Harvested sciatic nerve segments were investigated histopathologically and for tissue biochemistry. Results: Ischemic fiber degeneration scores were found significantly lower in syringic acid and MP groups than sham group. Additionally, apoptosis-related cysteine peptidase caspase-3 immunostaining scores were lower in syringic acid and MP groups. Biochemically, superoxide dismutase and nuclear respiratory factor 1 values were significantly higher in syringic acid group compared to those of control and sham groups while malondialdehyde levels were significantly lower in the syringic acid group. ConclusIon: Syringic acid reduces oxidative stress and axonal degeneration in rat sciatic nerve after ischemia/reperfusion injury. Therefore, syringic acid may play a role in the treatment of peripheral nerve injuries due to ischemia/reperfusion.