Wnt pathway: A mechanism worth considering in endocrine disrupting chemical action

ÜSTÜNDAĞ Ü. V., ALTURFAN E. I.

Toxicology and Industrial Health, vol.36, no.1, pp.41-53, 2020 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Review
  • Volume: 36 Issue: 1
  • Publication Date: 2020
  • Doi Number: 10.1177/0748233719898989
  • Journal Name: Toxicology and Industrial Health
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, Aerospace Database, Agricultural & Environmental Science Database, BIOSIS, Communication Abstracts, EMBASE, Environment Index, Index Islamicus, MEDLINE, Metadex, Pollution Abstracts, Civil Engineering Abstracts
  • Page Numbers: pp.41-53
  • Keywords: Endocrine disrupting chemical, Wnt signaling pathway, bisphenol A, phthalate
  • Istanbul Medipol University Affiliated: Yes

Abstract

Endocrine disrupting chemicals (EDCs) are defined as exogenous substances that can alter the development and functioning of the endocrine system. The Wnt signaling pathway is an evolutionarily conserved pathway consisting of proteins that transmit cell-to-cell receptors through cell surface receptors, regulating important aspects of cell migration, polarity, neural formation, and organogenesis, which determines the fate of the cell during embryonic development. Although the effects of EDCs have been studied in terms of many molecular mechanisms; because of its critical role in embryogenesis, the Wnt pathway is of special interest in EDC exposure. This review provides information about the effects of EDC exposure on the Wnt/β-catenin pathway focusing on studies on bisphenol A, di-(2-ethylhexyl) phthalate, diethylstilbestrol, cadmium, and 2,3,7,8-tetrachlorodibenzo-p-dioxin.