Apple cider vinegar supplementation modulates lipid peroxidation and glutathione peroxidase values in lens of ovariectomized mice

NAZIROĞLU M., Güler M., Küçükayaz M., Övey I. S., ÖZGÜL C.

Cell Membranes and Free Radical Research, vol.4, no.3, pp.209-214, 2012 (Scopus) identifier

  • Publication Type: Article / Article
  • Volume: 4 Issue: 3
  • Publication Date: 2012
  • Journal Name: Cell Membranes and Free Radical Research
  • Journal Indexes: Scopus
  • Page Numbers: pp.209-214
  • Keywords: Antioxidant, Glutathione peroxidase, Lens, Ovariectomize, Oxidative stress
  • Istanbul Medipol University Affiliated: Yes


Epidemiological studies reported that increased risk of cataracts and oxidative stress in postmenopausal women although aetiology of the mechanisms has not been clarified. Apple cider vinegar may useful treatment of ovariectomize (OVX)-induced oxidative lens injury via its antioxidant properties. We aimed to investigate effects of apple cider vinegar on lipid peroxidation, glutathione peroxidase (GSH-Px) and reduced glutathione (GSH) values in OVX mice fed high cholesterol. Thirty-two mice were used in the study and they were divided into four equal groups. First group was used as control. Second group was used OVX. Apple vinegar (0.6% of feed) was intragastrically giving to consisting apple vinegar and OVX+apple vinegar mice for 28 days. All groups except control group were fed cholesterol rich ration (5% cholesterol). After 28 days, lens samples are taken to study lipid profile and antioxidant values. Lipid peroxidation levels in the lens were higher in OVX group than in control whereas their levels were lower in apple vinegar and OVX+apple vinegar groups than in OVX group. The GSH-Px activities were lower in OVX group than in control although their activities were higher in apple vinegar and OVX+apple vinegar groups than in OVX group. The GSH levels did not change by OVX and apple vinegar administrations. In conclusion, apple cider vinegar decreased in lens oxidative injury by modulating GSH-Px in mice fed with high cholesterol.