Synthesis of substituted pyridines from 1,2-nucleophilic addition products of functionalized N-acyl-2,3-dihydropyridones
Tetrahedron Letters, cilt.56, sa.38, ss.5275-5277, 2015 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 56 Sayı: 38
- Basım Tarihi: 2015
- Doi Numarası: 10.1016/j.tetlet.2015.07.045
- Dergi Adı: Tetrahedron Letters
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.5275-5277
- Anahtar Kelimeler: Substituted pyridines, N-Acyl-2,3-dihydropyridones, Oxidative aromatization, Chloranil, 1,2-Nucleophilic addition
- İstanbul Medipol Üniversitesi Adresli: Evet
Özet
Abstract We describe herein a general and efficient synthetic approach toward substituted pyridines from functionalized N-acyl-2,3-dihydropyridones in two steps; 1,2-addition with organocerium reagents and subsequent oxidative aromatization with chloranil. This strategy allows the generation of pyridines with various substitution patterns and introduces a variety of substituents including aryl, alkyl, alkynyl, alkenyl, and heteroaryl groups at the desired positions.