Aim: It is aimed to evaluate the perception of occupational health and safety (OHS) competence of health workers during the COVID-19 pandemic and to identify deficiencies in order to develop appropriate solutions. Material and Methods: In the descriptive cross-sectional study, in which 550 health workers participated, the perception of occupational health and safety competence was measured with a web-based data collection form. Occupational Health and Safety Sufficiency Perception Scale (OHSAS) and a data collection form that includes socio-demographic characteristics such as gender, educational status, age, and work-related characteristics such as working time, having an occupational accident, and receiving OHS training were used. For descriptive and inferential data analysis, tests were performed using SPSS version 20.0. Results: In the study, 32.5% of the health workers were male and the mean age was 40.56±12.6% years. 16.5% of the employees had a work accident, and female employees stated that they had more work accidents than male employees (p=0.025). In the study, the mean score of OHSAS was 97.64±27.6. Female health workers, employees with university or higher education, those in the 31-45 age group, and those who practice the profession as physician/nurse have higher OHSAS scores (respectively p=0.024, p=0.007, p=0.014; p=0.013). It was determined that the participants' occupation (1.301, p=0.042) and having a work accident (0.106, p<0.001) affected the perception of OHS competence at a statistically significant level. Conclusion: Healthcare workers have a high risk of having occupational accidents and occupational diseases however their OHS competence perceptions are at an average level. Researches on the OHS competence of health workers should be planned at regular intervals and necessary political and institutional measures should be taken according to the results.