Does sleep disturbance affect the amyloid clearance mechanisms in Alzheimer's disease?

Yulug B., HANOĞLU L., Kilic E.

Psychiatry and Clinical Neurosciences, vol.71, no.10, pp.673-677, 2017 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Review
  • Volume: 71 Issue: 10
  • Publication Date: 2017
  • Doi Number: 10.1111/pcn.12539
  • Journal Name: Psychiatry and Clinical Neurosciences
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.673-677
  • Keywords: Alzheimer's disease, amyloid beta clearance, glymphatic system, sleep, sleep deprivation
  • Istanbul Medipol University Affiliated: Yes

Abstract

Sleep is an important factor that plays a key role in Alzheimer's disease pathogenesis. However, it is still unclear whether poor-quality sleep may overlap with sleep disturbances in the underlying dysfunctional mechanisms of amyloid beta (Aβ) clearance metabolism. Here, we aimed to evaluate the current evidence on the role of sleep deprivation in Aβ clearance metabolism. To that end, we discuss possible mechanisms underlying the bidirectional interaction between the sleep deprivation and Aβ clearance pathways.