Does sleep disturbance affect the amyloid clearance mechanisms in Alzheimer's disease?
Psychiatry and Clinical Neurosciences, cilt.71, sa.10, ss.673-677, 2017 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Derleme
- Cilt numarası: 71 Sayı: 10
- Basım Tarihi: 2017
- Doi Numarası: 10.1111/pcn.12539
- Dergi Adı: Psychiatry and Clinical Neurosciences
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.673-677
- Anahtar Kelimeler: Alzheimer's disease, amyloid beta clearance, glymphatic system, sleep, sleep deprivation
- İstanbul Medipol Üniversitesi Adresli: Evet
Özet
Sleep is an important factor that plays a key role in Alzheimer's disease pathogenesis. However, it is still unclear whether poor-quality sleep may overlap with sleep disturbances in the underlying dysfunctional mechanisms of amyloid beta (Aβ) clearance metabolism. Here, we aimed to evaluate the current evidence on the role of sleep deprivation in Aβ clearance metabolism. To that end, we discuss possible mechanisms underlying the bidirectional interaction between the sleep deprivation and Aβ clearance pathways.