Folliculotropic mycosis fungoides associated with alopecia in a case


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BALEVİ A., Özdemir M., Üstüner P. D., Toy H.

Turkiye Klinikleri Dermatoloji, vol.27, no.1, pp.20-23, 2017 (Scopus) identifier

  • Publication Type: Article / Article
  • Volume: 27 Issue: 1
  • Publication Date: 2017
  • Doi Number: 10.5336/dermato.2016-51209
  • Journal Name: Turkiye Klinikleri Dermatoloji
  • Journal Indexes: Scopus
  • Page Numbers: pp.20-23
  • Keywords: Alopecia areata, Mycosis fungoides, Skin neoplasms
  • Istanbul Medipol University Affiliated: Yes

Abstract

Mycosis fungoides (MF) is the most common type of cutaneous lymphoma and characterized by proliferation of small to medium T lymphocytes with cerebriform nuclei in most cases. However, the diagnosis of MF may be very difficult in certain cases, particularly in those variants of MF such assyringotropic MF, granulomatous MF and folliculotropic MF. The classic histopathologic feature is the presence of atypical T-cells with a tropism to hair follicle epithelium. The clinical presentation of folliculotropic MF often differs from the patches and plaques of classic MF and may be associated with decreased clinical suspicion for folliculotropic MF. The average time interval from onset of lesions till diagnosis of folliculotropic MF was 2 years. Folliculotropic MF displays resistance to standard treatment modalities, has an unfavourable course and diversity in the histological spectrum. Here we reported a rare case who presented to our dermatology polyclinic with a complaint of hair loss on his back firstly. On the follow-up, the case was diagnosed as folliculotropic MF and treated with interferon-i2a and PUVA successfully.