Wound healing effects of methanol extract of Laurocerasus officinalis roem

Ayla S., Okur M., Günal M., Özdemir E., ÇİÇEK POLAT D., Yoltaş A., ...More

Biotechnic and Histochemistry, vol.94, no.3, pp.180-188, 2019 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 94 Issue: 3
  • Publication Date: 2019
  • Doi Number: 10.1080/10520295.2018.1539242
  • Journal Name: Biotechnic and Histochemistry
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.180-188
  • Keywords: Antimicrobial, antioxidant, extract, Laurocerasus officinalis, mice, wound healing
  • Istanbul Medipol University Affiliated: Yes


Laurocerasus officinalis Roem. (syn: Prunus laurocerasus L.) is a member of Rosaceae family. We investigated the antimicrobial and antioxidant activity of L. officinalis Roem in wound healing both in vivo and in vitro using an excisional wound model model in mice. We used four groups of eight mice as follows: untreated (control), empty gel, extract + gel (L. officinalis + gel), and Madecassol® groups. All treatments were applied topically once daily. The scar area, percentage wound closure and epithelization time were measured. L. officinalis promoted wound healing and increased granulation tissue, epidermal regeneration and angiogenesis. L. officinalis extract, which is known for its antioxidant and antimicrobial activities, may be useful for promoting wound healing.