Synthesis and cytotoxicity studies on novel piperazinylacetamides

Bobtaina E., Gurdal E. E., Durmaz I., Atalay R. C., Yarim M.

Letters in Drug Design and Discovery, vol.16, no.1, pp.45-51, 2018 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 16 Issue: 1
  • Publication Date: 2018
  • Doi Number: 10.2174/1570180815666180501124009
  • Journal Name: Letters in Drug Design and Discovery
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.45-51
  • Keywords: Acetamide, anticancer, benzhydrylpiperazine, cytotoxicity, piperazine, sulforhodamine B
  • Istanbul Medipol University Affiliated: No


Background: In this study, nine novel compounds, bearing N-[2-(4-substituted piperazine-1-yl)acetyl]-N’-[bis-(4-fluorophenyl)methyl]piperazine structures were synthesized. Methods: Their cytotoxic properties were evaluated in vitro by NCI-60 Sulforhodamine B (SRB) assay against human cancer cell lines: Huh7 (hepatocellular), MCF7 (breast) and HCT116 (colorectal). Results and Conclusion: According to the activity data, most of the compounds are more cytotoxic than 5-fluorouracil against Huh7 and HCT116 cancer cell lines.