Antituberculosis activity of hydrazones derived from 4-fluorobenzoic acid hydrazide

Koçyiǧit-KaymakçIoǧlu B., Elçin Oruç-Emre E., Unsalan S., Rollas S.

Medicinal Chemistry Research, vol.18, no.4, pp.277-286, 2009 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 18 Issue: 4
  • Publication Date: 2009
  • Doi Number: 10.1007/s00044-008-9126-z
  • Journal Name: Medicinal Chemistry Research
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.277-286
  • Keywords: Hydrazide-hydrazones, Antituberculosis activity, 4-fluorobenzoic acid hydrazide
  • Istanbul Medipol University Affiliated: No


A series of substitututed methylene/ethylene 4-fluorophenylhydrazide derivatives (3a-p) was synthesized with the aim of evaluating their antimycobacterial activity toward a strain of Mycobacterium tuberculosis H37Rv. Their chemical structures were confirmed by 1H-nuclear magnetic resonance (NMR) and electrospray mass spectrometry (ES-MS) spectral data, and elemental analysis. The in vitro antimycobacterial evaluation was performed according to the Tuberculosis Antimicrobial Acquisition and Coordinating Facility (TAACF) antituberculosis drug discovery program. Compound 3a, 4-fluorobenzoic acid [(2,6-dichlorophenyl) methylene]hydrazide, showed the highest inhibitory activity of all the compounds under study. © 2008 Birkhäuser Boston.