Akademik Veri Yönetim Sistemi
International Journal of Neuroscience, cilt.112, sa.8, ss.1001-1009, 2002 (SCI-Expanded)
This study aimed to investigate the usefulness of auditory evoked potentials (AEPs) in rats. To this end, N1, P2 latencies, and the N1-P2 amplitude of responses to different acoustic stimuli from rats, which were implanted with permanent electrodes in the inferior collictdus (1C), were evaluated and used to demonstrate the frequency characteristics of IC region. Permanent electrodes were implanted in IC regions of 7 male albino rats by the stereotaxic method. The animals were exposed to five tones series of stimuli (1000 Hz, 2000 Hz, 4000 Hz, 6000 Hz, and 8000 Hz tones with 1500 ms interstimulus intervals) of 70 dB with a duration of 1000 ms. AEPs)were recorded and analyzed with the Brain-Data Acquisition system. There were no statistically significant differences in N1, P2 latencies, and the N1-P2 amplitude of AEPs from IC regions of rats as a result of changes in the frequency of stimulus. It was determined that the dominant frequency activity of the IC to acoustic stimulus was theta-alpha band, with theta as the peak frequency. As a result it was concluded that there are similarities between the N1, P2 components of rat AEPs, and human AEPs. We have suggested that the rats may provide a useful model for investigating the generation of middle latency components of AEPs in humans.