A histopathological research about the effects of dimenhydrinate and ondansetron were used on pregnant rats on the young rats' organs during postnatal period Gebe ratlarda kullanilan dimenhidrinat ve ondansetronun postnatal dönemdeki yavru ratlarin organlarinda oluşturacaǧi etkilerin histopatolojik yönden araştirilmasi
Turkiye Klinikleri Jinekoloji Obstetrik, cilt.20, sa.3, ss.149-154, 2010 (Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 20 Sayı: 3
- Basım Tarihi: 2010
- Dergi Adı: Turkiye Klinikleri Jinekoloji Obstetrik
- Derginin Tarandığı İndeksler: Scopus
- Sayfa Sayıları: ss.149-154
- Anahtar Kelimeler: Antiemetics, Dimenhydrinate, Ondansetron, Pregnancy
- İstanbul Medipol Üniversitesi Adresli: Evet
Özet
Objective: We aimed to research the effects of Dimenhydrinate (DMH) and Ondansetron, used during pregnancy, on the organs of young rats in postnatal period in terms of histopathologically. Material and Methods: In the study, 30 Wistar-Albino type female rats have been used. The rats have been divided into three groups: group 1 (control, n: 10), group 2 (DMH, n: 10) and group 3 (ondansetron, n: 10). We kept them together for pregnancy starting from the first day of pregnancy, a dose of 115 mg/kg/day intramuscular DMH (group 2) and 10 mg/kg/day intraperitoneally ondansetron (group 3) have been given to pregnant rats for a week. As for the control group (group 1), a dose of intramuscular 0.9% NaCl has been given for the same period of time. After birth, the numbers of babies have been ascertained. Brain, lung, heart, liver and kidney tissues have been taken from the babies of each group during their newborn, lactation and adulthood periods. After histologic tissue follow-up methods, the preparates have been painted with Haematoxylin-Eosin (H&E) and then evaluated underlight microscope. Results: There was no significant difference between the controls and experiment groups in point of histopathological change on the organs of the young rats. Conclusion: It has been concluded that DMH and ondansetron treatment during pregnancy period has no histopathological effect on the organs of the young rats. Copyright © 2010 by Türkiye Klinikleri.