Long-term Outcome of Patients With Undiagnosed Pleural Effusion Resultados del seguimiento a largo plazo de pacientes con derrame pleural no diagnosticado

Gunluoglu G., Olcmen A., GÜNLÜOĞLU M. Z., Dincer I., Sayar A., Camsari G., ...More

Archivos de Bronconeumologia, vol.51, no.12, pp.632-636, 2015 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 51 Issue: 12
  • Publication Date: 2015
  • Doi Number: 10.1016/j.arbr.2015.09.021
  • Journal Name: Archivos de Bronconeumologia
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.632-636
  • Keywords: Exudative pleural effusion, Idiopathic pleuritis, Nonspecific, Pleuritis, Video-assisted thoracoscopic surgery
  • Istanbul Medipol University Affiliated: Yes


Introduction: The cause of exudative pleural effusion cannot be determined in some patients. The longterm outcomes of patients with undiagnosed pleural effusion were analyzed. Methods: Patients with exudative pleural effusion whose diagnostic procedures included pleural biopsy using video-assisted thoracoscopic surgery carried out between 2008 and 2012 were evaluated retrospectively. Patients diagnosed with non-specific pleuritis were included. Fifty-three patients with available follow-up data were included in the study. Results: Forty men and 13 women (mean age 53.9 ± 13.9 years) were included. Median follow-up time was 24 months. No diagnosis was given in 27 patients (51%), and a clinical diagnosis was given in 26 patients (49%) during the follow-up period. Malignant disease (malignant mesothelioma) was diagnosed in 2 (3.7%) patients. Other diseases were parapneumonic effusion in 12, congestive heart failure in 8, and miscellaneous in 4 patients. Volume of effusion at the time of initial examination and re-accumulation of fluid after video-assisted thoracoscopic surgery were associated with malignant disease (P = .004 and .0001, respectively). Conclusion: Although the probability is low, some patients with exudative pleural effusion undiagnosed after pleural biopsy via video-assisted thoracoscopic surgery may have malignant disease. Patients with an initially large volume of effusion that re-accumulates after examination should be closely monitored.