Mesenchymal stem cell applications in polycystic ovary syndrome treatment


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Bulbul M. V., Yildirim B., KOLBAŞI B., KESKİN İ.

Journal of Experimental and Clinical Medicine (Turkey), vol.38, no.3, pp.361-366, 2021 (Scopus) identifier

Abstract

Mesenchymal stem cells (MSCs) are highly capable of self-renewal and differentiation. They can be isolated from a variety of sources such as adipose tissue, bone marrow, umbilical cord, tooth pulp and can be cultured under in vitro conditions. MSCs have anti-inflammatory, anti-apoptotic, angiogenic, immunomodulatory and many more therapeutic effects because of paracrine factors they secrete. Today, mesenchymal stem cells are used for treatment in more than twenty diseases, from spinal cord injuries to diabetes. However, there is little mention in the literature of the use of these cells in female reproductive system diseases. In this review, a limited number of clinical and experimental studies on the use of mesenchymal stem cells in the treatment of polycystic ovary syndrome, which is quite common in women, were examined and analyzed.