Nanodrugs for the Treatment of Ischemic Stroke: A Systematic Review

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Ruscu M., Cercel A., Kilic E., Catalin B., Gresita A., Hermann D. M., ...More

International Journal of Molecular Sciences, vol.24, no.13, 2023 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Review
  • Volume: 24 Issue: 13
  • Publication Date: 2023
  • Doi Number: 10.3390/ijms241310802
  • Journal Name: International Journal of Molecular Sciences
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, CAB Abstracts, EMBASE, Food Science & Technology Abstracts, MEDLINE, Veterinary Science Database, Directory of Open Access Journals
  • Keywords: animal models, biodistribution, nanodrugs, neuroinflammation, neurorestoration, stroke, toxicity
  • Istanbul Medipol University Affiliated: Yes


Ischemic stroke, a significant neurovascular disorder, currently lacks effective restorative medication. However, recently developed nanomedicines bring renewed promise for alleviating ischemia’s effects and facilitating the healing of neurological and physical functions. The aim of this systematic review was to evaluate the efficacy of nanotherapies in animal models of stroke and their potential impact on future stroke therapies. We also assessed the scientific quality of current research focused on nanoparticle-based treatments for ischemic stroke in animal models. We summarized the effectiveness of nanotherapies in these models, considering multiple factors such as their anti-inflammatory, antioxidant, and angiogenetic properties, as well as their safety and biodistribution. We conclude that the application of nanomedicines may reduce infarct size and improve neurological function post-stroke without causing significant organ toxicity.