Utilization of Clinical Data and Evaluation of Biomarkers in the Investigation of Graft-Versus-Host Disease Outcomes

Çelik S., Kaynar L.

in: Graft-Versus-Host Disease Methods and Protocols, Sluyter Ronald, Editor, Humana Press Inc, New York, pp.71-83, 2025

  • Publication Type: Book Chapter / Chapter Vocational Book
  • Publication Date: 2025
  • Publisher: Humana Press Inc
  • City: New York
  • Page Numbers: pp.71-83
  • Editors: Sluyter Ronald, Editor
  • Istanbul Medipol University Affiliated: Yes

Abstract

Graft-versus-host disease (GVHD) is one of the most important obstacles after allogeneic hematopoietic stem cell transplantation (allo-HCT). The mortality rate is around 50%, especially in severe GVHD. One of the most important clinical outcomes in GVHD is non-relapse mortality (NRM). NRM was defined as death without evidence of relapse or progression. Kaplan Meier, log-rank test, and Cox model are used in survival analysis methods. There are various biomarkers that assess clinical outcomes of GVHD. Damage-associated molecular patterns, pathogen-associated molecular patterns, microRNAs, markers of endothelial dysfunction, cytokines, and their receptors are used to predict the occurrence of GVHD and clinical outcomes in GVHD. Furthermore, the utilization of panels that assess many biomarkers has proven to be successful in predicting the clinical outcomes of GVHD, particularly NRM.