Channel estimation is an integral part of receiver designs in coherent OFDM systems. Moreover channel estimation is a challenging problem in wireless systems, due to time variation of the multipath channel. In this paper, a time domain channel estimation method for rapidly time varying channel in LTE Uplink, which we have been proposed previously is further studied in the presence of guard band and multiple access. Since the presence of guard band and multiple access results in leakage, we therefore propose a new approach to reduce leakage on the number of taps which are to be tracked by Kalman Filter. ©2010 IEEE.