Effectiveness of the systemic immune inflammation index to predict atrial fibrillation recurrence after cryoablation

Kaplan E., Eklzler F. A., Saribas H., Tak B. T., Cay S., Korkmaz A., ...More

Biomarkers in Medicine, vol.17, no.2, pp.101-109, 2023 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 17 Issue: 2
  • Publication Date: 2023
  • Doi Number: 10.2217/bmm-2022-0515
  • Journal Name: Biomarkers in Medicine
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Chemical Abstracts Core, EMBASE, MEDLINE
  • Page Numbers: pp.101-109
  • Keywords: atrial fibrillation, biomarker, cryoballoon ablation, inflammation, recurrence, systemic immune inflammation index
  • Istanbul Medipol University Affiliated: Yes


Background: We aimed to investigate the predictive role of systemic immune inflammation index (SII) on atrial fibrillation (AF) recurrence following cryoballoon-based AF ablation. Materials & methods: A total of 370 consecutive patients with symptomatic AF who underwent cryoablation were enrolled. The patients were divided into two groups according to recurrence development. Results: During the follow-up period of 25.0 ± 6.7 months, recurrence was observed in 77 patients (20.8%). Receiver operating characteristic analysis demonstrated that using a cutoff level of 532, SII had a sensitivity of 71% and specificity of 68%. In the multivariate Cox model, high SII was a significant predictor of the recurrence. Conclusion: This study showed that higher SII level is an independent predictor of AF recurrence.