Periodontitis is a common infectious disease that causes damage to the periodontal sup- porting tissues and can result in tooth loss. The aim of periodontal therapy is to restore the structure and function of periodontal tissues through periodontal regeneration by stimulating the desired cell types. In recent years, research has been conducted to produce reliable and predictable materials for use in peri- odontal regenerative therapy and to improve the properties of currently used skeletal structures, mem- branes, and hard tissue grafts. Graphene is a new material of great interest in biomedical fields. Due to its exceptional mechanical, electrical, and chemical properties, as well as its osteogenic and regenerative properties, its incorporation into materials used in regenerative dentistry is on the agenda. This chapter presents the state of the art of periodontal regeneration applications with graphene based materials, fo- cusing on the control of graphene and its derivatives on stem cells of dental origin.