Research Information System
The European Journal of Cancer, vol.9, pp.1-12, 2025 (Peer-Reviewed Journal)
Objectives and Background: Carcinoid tumors (CTs) are neuroendocrine tumors with good prognosis, divided into two groups: typical and
atypical. Although they share morphological, ultrastructural, and molecular features, their epidemiology, biological behavior, and evolution are
markedly different. The aim of this study was to determine the factors affecting overall survival and type differentiation in pulmonary carcinoid
patients.
Materials and methods: We retrospectively reviewed all surgical lung resectioncases from 2017 to 2023 with a diagnosis of primary CT.
We collected clinicopathologic parameters,including tumor size, nodal status, histologic pattern, presence of lymphovascular invasion, nuclear
atypia, microscopic invasion, mitotic count, and %Ki-67 positive cells (Ki-67 index).
Results: The optimal diagnostic cut-off level for distinguishing typical (T) from atypical carcinoid (AC) in cases was 10 for ki-67 levels (AUC value
0.64, 95% CI 0.47- 077, sensitivity and specificity was 85% and 32%, respectively). It was observed that the presence of necrosis (p= 0.003), and
ki-67 levels (p=0.048) were found to be significantly lower in TC patients than in AC patients. The overall 5-year survival rate of the patients was
calculated as 89%. Factors found to affect survival rate in univariate analysis were age, Ki-67 index, necrosis status and location.
Conclusion: Age, presence of necrosis and Ki-67 index are associated with survival in patients with surgically resected lung carcinoid.