Therapeutic role of rifampicin in Alzheimer's disease

Yulug B., HANOĞLU L., Ozansoy M., Isık D., Kilic U., Kilic E., ...Daha Fazla

Psychiatry and Clinical Neurosciences, cilt.72, sa.3, ss.152-159, 2018 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Derleme
  • Cilt numarası: 72 Sayı: 3
  • Basım Tarihi: 2018
  • Doi Numarası: 10.1111/pcn.12637
  • Dergi Adı: Psychiatry and Clinical Neurosciences
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.152-159
  • Anahtar Kelimeler: Alzheimer's disease, amyloid beta clearance, neuroprotection, oligomeric amyloid hypothesis, rifampicin
  • İstanbul Medipol Üniversitesi Adresli: Evet

Özet

Rifampicin exerts significant brain protective functions in multiple experimental models. Here we summarize the underlying mechanisms of the neuroprotective and pro-cognitive effects of rifampicin that are mediated by its anti-inflammatory, anti-tau, anti-amyloid, and cholinergic effects. Beyond suggesting that rifampicin shows strong brain protective effects in preclinical models of Alzheimer's disease, we also provide substantial clinical evidence for the neuroprotective and pro-cognitive effects of rifampicin. Future neuroimaging studies combined with clinical assessment scores are the following steps to be taken in this field of research.