Therapeutic role of rifampicin in Alzheimer's disease
Psychiatry and Clinical Neurosciences, cilt.72, sa.3, ss.152-159, 2018 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Derleme
- Cilt numarası: 72 Sayı: 3
- Basım Tarihi: 2018
- Doi Numarası: 10.1111/pcn.12637
- Dergi Adı: Psychiatry and Clinical Neurosciences
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.152-159
- Anahtar Kelimeler: Alzheimer's disease, amyloid beta clearance, neuroprotection, oligomeric amyloid hypothesis, rifampicin
- İstanbul Medipol Üniversitesi Adresli: Evet
Özet
Rifampicin exerts significant brain protective functions in multiple experimental models. Here we summarize the underlying mechanisms of the neuroprotective and pro-cognitive effects of rifampicin that are mediated by its anti-inflammatory, anti-tau, anti-amyloid, and cholinergic effects. Beyond suggesting that rifampicin shows strong brain protective effects in preclinical models of Alzheimer's disease, we also provide substantial clinical evidence for the neuroprotective and pro-cognitive effects of rifampicin. Future neuroimaging studies combined with clinical assessment scores are the following steps to be taken in this field of research.