Therapeutic role of rifampicin in Alzheimer's disease

Yulug B., HANOĞLU L., Ozansoy M., Isık D., Kilic U., Kilic E., ...More

Psychiatry and Clinical Neurosciences, vol.72, no.3, pp.152-159, 2018 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Review
  • Volume: 72 Issue: 3
  • Publication Date: 2018
  • Doi Number: 10.1111/pcn.12637
  • Journal Name: Psychiatry and Clinical Neurosciences
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.152-159
  • Keywords: Alzheimer's disease, amyloid beta clearance, neuroprotection, oligomeric amyloid hypothesis, rifampicin
  • Istanbul Medipol University Affiliated: Yes

Abstract

Rifampicin exerts significant brain protective functions in multiple experimental models. Here we summarize the underlying mechanisms of the neuroprotective and pro-cognitive effects of rifampicin that are mediated by its anti-inflammatory, anti-tau, anti-amyloid, and cholinergic effects. Beyond suggesting that rifampicin shows strong brain protective effects in preclinical models of Alzheimer's disease, we also provide substantial clinical evidence for the neuroprotective and pro-cognitive effects of rifampicin. Future neuroimaging studies combined with clinical assessment scores are the following steps to be taken in this field of research.