Ocular surface and tear parameters in patients with chronic hepatitis c at initial stages of hepatic fibrosis

Erdur S. K., KARADENİZ D., KOCABORA M. S., ÖZSÜTÇÜ M., Gulkilik I. G., DEMİRCİ G., ...Daha Fazla

Eye and Contact Lens, cilt.41, sa.2, ss.117-120, 2015 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 41 Sayı: 2
  • Basım Tarihi: 2015
  • Doi Numarası: 10.1097/icl.0000000000000079
  • Dergi Adı: Eye and Contact Lens
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.117-120
  • Anahtar Kelimeler: Tear film, Hepatitis C, Dry eye disease, Ocular surface
  • İstanbul Medipol Üniversitesi Adresli: Evet

Özet

Purpose: The aim of this study was to evaluate changes in ocular surface and tear function parameters in chronic hepatitis C at initial stages of hepatic fibrosis. Methods: Thirty-one patients with biopsy-proven chronic hepatitis C and 31 age- and sex-matched healthy control subjects without systemic hepatitis C infection were examined with the Ocular Surface Disease Index (OSDI) questionnaire, Schirmer I, tear film break-up time, and scoring of ocular surface fluorescein and Rose Bengal staining using modified Oxford and van Bijsterveld scoring systems, respectively. Results: All ocular surface parameters, except OSDI and corneal staining scores, were significantly worse in hepatitis C group. The control group had greater OSDI scores than the hepatitis C group, but there was no statistically important difference. In subgroup analysis, progression of hepatic fibrosis was found to be correlated strongly with decreased Schirmer test I, increased OSDI, lid parallel conjunctival folds, conjunctival, and corneal staining scores. Conclusion: Patients with chronic hepatitis C were more likely to exhibit severe ocular surface damage and signs of dry eye.