Immunomodulator Effect of Topical Zinc Oxide Application in Tuberculin Skin Test

Creative Commons License

NUHOĞLU Ç., HEPKAYA E., ÖNAL Z. E., AKICI N., GÜRBÜZ T., ATASAYAN V., ...Daha Fazla

İstanbul Kuzey Klinikleri, cilt.5, sa.1, ss.37-40, 2018 (Hakemli Dergi) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 5 Sayı: 1
  • Basım Tarihi: 2018
  • Doi Numarası: 10.14744/nci.2017.88896
  • Dergi Adı: İstanbul Kuzey Klinikleri
  • Derginin Tarandığı İndeksler: TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.37-40
  • Anahtar Kelimeler: Purified protein derivative, tuberculin skin test, zinc
  • İstanbul Medipol Üniversitesi Adresli: Evet

Özet

OBJECTIVE: We aimed to evaluate the sensitivity of tuberculin skintest (purified protein derivative-PPD) by topical zinc application on test site to improve diagnostic reliability.METHODS: We performed this study in 100 children aged 6–14 years, and plasma zinc levels were analyzed after 10–12 hours fasting. After PPD,we applied 40% zinc oxide cream on one forearm and placebo on the other forearm. PPD indurations were measured 72 hours later.RESULTS: In this study, 26% of the children showed increases in PPD induration following local zinc applications. There was no correlation between indurations size and serum zinc levels.CONCLUSION: We concluded that topical zinc cream application can enhance sensitivity of tuberculin reactivityin the diagnosis of tuberculosis.