Graft-versus-host disease in a child with neuroblastoma after autologous stem cell transplantation

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YAMAN Y., BAYSOY G., Keleşoğlu E., ÖZDİLLİ K., ÇAKIR A., Genç D. B., ...More

Wspolczesna Onkologia, vol.23, no.1, pp.59-62, 2019 (Scopus) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 23 Issue: 1
  • Publication Date: 2019
  • Doi Number: 10.5114/wo.2019.83815
  • Journal Name: Wspolczesna Onkologia
  • Journal Indexes: Scopus
  • Page Numbers: pp.59-62
  • Keywords: graft-versus-host disease, child, neuroblastoma, autologous stem cell transplantation
  • Istanbul Medipol University Affiliated: Yes

Abstract

In the pediatric population, hematopoietic stem cell transplantation (HSCT) is used to treat a wide variety of diseases, both malignant and nonmalignant. For many of these diseases, HSCT is a well-established treatment. Acute graft-versus-host disease (GVHD) continues to be a leading cause of morbidity and mortality after allogeneic hematopoietic stem cell transplantation. Graft versus host disease is a common complication of allo-SCT which is induced by donor T cell recognition of recipient alloantigens. The occurrence of autologous GVHD suggests that inappropriate recognition of host self-antigens may occur. GVHD in patients who received autologous HSCT is extremely rare compared to patients who received allogeneic HSCT. We present the case of a 4-year-old girl with metastatic neuroblastoma who spontaneously developed autologous GVHD after autologous HSCT.