Investigation of The Effect of Adalimumab on Experimental Brain Injury in Mice


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GÜNAL M. Y., ÇANKAYA S., TÖNÜK Ş. B., ÖZDEMİR E. M., SAYIN ŞAKUL A. A.

Acta Medica Alanya, vol.3, no.3, pp.306-310, 2019 (Peer-Reviewed Journal) identifier

  • Publication Type: Article / Article
  • Volume: 3 Issue: 3
  • Publication Date: 2019
  • Doi Number: 10.30565/medalanya.632455
  • Journal Name: Acta Medica Alanya
  • Journal Indexes: TR DİZİN (ULAKBİM)
  • Page Numbers: pp.306-310
  • Istanbul Medipol University Affiliated: Yes

Abstract

Aim: We aimed to investigate the neuroprotective role of adalimumab based onthe hypothesis that "TNF-alpha inhibitor adalimumab may affect inflammationrelated neuronal injury due to its anti-inflammatory effect".Methods: To investigate the effects of adalimumab, we induced brain injury inmice using a cold trauma model and evaluated the underlying cell survival/ deathmechanisms via cresyl violet and calculated infarct/edema volume with imageanalyze system.Results: Although our data indicated a tendency to decreased infarct and edemavolume, these findings are not significant statistically.Conclusion: To the best of our knowledge, this is the first study evaluating theneuroprotective effect of adalimumab on injured neurons.