Investigation of The Effect of Adalimumab on Experimental Brain Injury in Mice

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GÜNAL M. Y., ÇANKAYA S., TÖNÜK Ş. B., ÖZDEMİR E. M., SAYIN ŞAKUL A. A.

Acta Medica Alanya, cilt.3, sa.3, ss.306-310, 2019 (Hakemli Dergi) identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 3 Sayı: 3
  • Basım Tarihi: 2019
  • Doi Numarası: 10.30565/medalanya.632455
  • Dergi Adı: Acta Medica Alanya
  • Derginin Tarandığı İndeksler: TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.306-310
  • İstanbul Medipol Üniversitesi Adresli: Evet

Özet

Aim: We aimed to investigate the neuroprotective role of adalimumab based onthe hypothesis that "TNF-alpha inhibitor adalimumab may affect inflammationrelated neuronal injury due to its anti-inflammatory effect".Methods: To investigate the effects of adalimumab, we induced brain injury inmice using a cold trauma model and evaluated the underlying cell survival/ deathmechanisms via cresyl violet and calculated infarct/edema volume with imageanalyze system.Results: Although our data indicated a tendency to decreased infarct and edemavolume, these findings are not significant statistically.Conclusion: To the best of our knowledge, this is the first study evaluating theneuroprotective effect of adalimumab on injured neurons.