Synthesis and characterization of triazenes derived from sulfonamides Sülfonamitlerden türeyen triazenlerin sentezi ve karakterizasyonu


Ünsalan S., Çikla P., Güniz Küçükgüzel Ş., Rollas S., Şahin F., Faruk Bayrak Ö.

Marmara Pharmaceutical Journal, cilt.15, sa.1, ss.11-17, 2011 (Scopus) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 15 Sayı: 1
  • Basım Tarihi: 2011
  • Doi Numarası: 10.12991/201115439
  • Dergi Adı: Marmara Pharmaceutical Journal
  • Derginin Tarandığı İndeksler: Scopus
  • Sayfa Sayıları: ss.11-17
  • Anahtar Kelimeler: Triazene, sulfonamide, prontosil, azo reduction
  • İstanbul Medipol Üniversitesi Adresli: Hayır

Özet

A series of novel triazene derivatives 1-3, 1a-3a were synthesized by the coupling of diazonium salts of amines (sulfaguanidine, sulfapyridine, sulfamethoxazole) with N-methylaniline / p-nitroaniline in acidic media. The structures of the synthesized compounds were confirmed by the spectral data (UV, IR, 1H-NMR, APCI-MS) and elemental analysis. The effects of all the compounds on A 549 and L 929 cell lines growth were investigated. The cytotoxic and antitumor activities of these compounds have not been in vitro aganist A 549 and L 929 cell lines.