Synthesis and characterization of triazenes derived from sulfonamides Sülfonamitlerden türeyen triazenlerin sentezi ve karakterizasyonu

Ünsalan S., Çikla P., Güniz Küçükgüzel Ş., Rollas S., Şahin F., Faruk Bayrak Ö.

Marmara Pharmaceutical Journal, vol.15, no.1, pp.11-17, 2011 (Scopus) identifier identifier

  • Publication Type: Article / Article
  • Volume: 15 Issue: 1
  • Publication Date: 2011
  • Doi Number: 10.12991/201115439
  • Journal Name: Marmara Pharmaceutical Journal
  • Journal Indexes: Scopus
  • Page Numbers: pp.11-17
  • Keywords: Triazene, sulfonamide, prontosil, azo reduction
  • Istanbul Medipol University Affiliated: No


A series of novel triazene derivatives 1-3, 1a-3a were synthesized by the coupling of diazonium salts of amines (sulfaguanidine, sulfapyridine, sulfamethoxazole) with N-methylaniline / p-nitroaniline in acidic media. The structures of the synthesized compounds were confirmed by the spectral data (UV, IR, 1H-NMR, APCI-MS) and elemental analysis. The effects of all the compounds on A 549 and L 929 cell lines growth were investigated. The cytotoxic and antitumor activities of these compounds have not been in vitro aganist A 549 and L 929 cell lines.