A rare but severe complication of filgrastim in a healthy donor: Splenic rupture

AKYOL G., Pala C., Yildirim A., Keklika M., Demir K., Dortdudak S., ...More

TRANSFUSION AND APHERESIS SCIENCE, vol.50, no.1, pp.53-55, 2014 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 50 Issue: 1
  • Publication Date: 2014
  • Doi Number: 10.1016/j.transci.2013.07.036
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.53-55
  • Keywords: Splenic rupture, Filgrastim, Stem cell transplantation
  • Istanbul Medipol University Affiliated: No


Background: Granulocyte-colony stimulating factor (G-CSF) is widely administered to donors who provide peripheral blood stem cells (PBSCs) for individuals who undergo hematopoietic stem cell transplants. G-CSF administration is associated with a small but definite risks of serious adverse events like splenic rupture. Case Study: In this case, we report a 40. year old women, a healthy donor for her sister who has aplastic anemia, who had sharp left upper abdominal pain on the forth mobilization day. The diagnosis at CT scan was splenic rupture; irregular intrasplenic low-attenuation areas consistent with ruptured spleen and perisplenic high density fluid. Her bidimensional spleen size was 16. ×. 6. cm. Results: She was followed conservatively. One month later the CT scan signs of rupture disappeared. Conclusion: We must pay attention to this rare but serious adverse event during filgrastim use. © 2013 Elsevier Ltd.