Synthesis of new tandospirone analogues carrying 1-(3-(trifluoromethyl) phenyl)piperazine

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GÜNKARA Ö. T., SUCU B. O., Guleli M., Ocal N.

Synthetic Communications, vol.44, no.11, pp.1619-1628, 2014 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 44 Issue: 11
  • Publication Date: 2014
  • Doi Number: 10.1080/00397911.2013.865236
  • Journal Name: Synthetic Communications
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.1619-1628
  • Keywords: Antidepressant drugs, C-C coupling, isoindoles, spiro-1,3-indandionolylpyrrolidines, tandospirone
  • Istanbul Medipol University Affiliated: Yes


New tandospirone analogues containing a 1-[3-(trifluoromethyl)phenyl] piperazine (TFMPP) moiety have been synthesized by hydroarylation reactions with Pd(OAc)2. The perhydroisoindole derivatives were obtained by the reaction of reduced starting material with aryl-(heteroaryl) iodides under the same conditions. Spiro-1,3-indandionolylpyrrolidine derivatives having an array of stereocenters are reported. © 2014 Copyright Taylor & Francis Group, LLC.