Retinal nerve fiber layer and ophthalmic artery blood flow parameters in pseudoexfoliation syndrome and pseudoexfoliative glaucoma Paramètres de la couche fibreuse du nerf rétinien et du débit sanguin de l'artère ophtalmique dans le syndrome de pseudo-exfoliation et le glaucome pseudo-exfoliatif

Koc H., Ipeksoy U., KAYA F.

Journal Francais d'Ophtalmologie, vol.46, no.8, pp.857-865, 2023 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 46 Issue: 8
  • Publication Date: 2023
  • Doi Number: 10.1016/j.jfo.2023.01.007
  • Journal Name: Journal Francais d'Ophtalmologie
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, PASCAL, CAB Abstracts, EMBASE, MEDLINE, Veterinary Science Database
  • Page Numbers: pp.857-865
  • Keywords: Color Doppler, Glaucoma, Ophthalmic artery, Pseudoexfoliation, Retinal nerve fiber layer
  • Istanbul Medipol University Affiliated: Yes


Objectives: To investigate the relationship between ophthalmic artery (OA) blood flow parameters and retinal nerve fiber layer (RNFL) thickness in eyes with pseudoexfoliation (PEX). Methods: We compared PEX eyes without glaucoma (group A, n = 53) and those with glaucoma (group B, n = 18) with control eyes (group C, n = 44). Subsequently, eyes in groups A and B were compared. Finally, OA color Doppler imaging measurements were recorded, and peripapillary RNFL analysis was performed. Results: The total RNFL measurements differed significantly among the groups (P = 0.012), being thicker in group C than in group A (P = 0.010) and significantly different between group B and groups A and C (both P = 0.001). The peak systolic velocity (PSV) and end diastolic velocity (EDV) measurements of groups A and B were lower than those of group C (PSV: P = 0.001 and P = 0.001, respectively; EDV: P = 0.001 and P = 0.001, respectively). No significant difference was noted in resistive index (RI) measurements (P = 0.370). In group B, significant negative correlations were noted between total RNFL and PSV (r = –0.743; P = 0.001) and between total RNFL and EDV (r = –0.691; P = 0.001), but not between total RNFL and RI measurements (P = 0.548). Conclusions: Pseudoexfoliation syndrome (PXS) with or without glaucoma was associated with a decrease in the PSV and EDV values of the OA. An extensive study may be needed to further explore the role of PXS in OA blood flow parameters. Total RNFL thickness values were lower in eyes with PEX than in those without.