Fructose consumption correlates with triglyceride-glucose index and glycemic status in healthy adults

Keskin E., Yoldas Ilktac H.

Clinical Nutrition ESPEN, vol.52, pp.184-189, 2022 (ESCI) identifier identifier

  • Publication Type: Article / Article
  • Volume: 52
  • Publication Date: 2022
  • Doi Number: 10.1016/j.clnesp.2022.11.008
  • Journal Name: Clinical Nutrition ESPEN
  • Journal Indexes: Emerging Sources Citation Index (ESCI), Scopus, CAB Abstracts, EMBASE, Food Science & Technology Abstracts, MEDLINE, Veterinary Science Database
  • Page Numbers: pp.184-189
  • Keywords: Fructose, Glucose, Glycemic control, Insulin, Lipids, Triglyceride-glucose index
  • Istanbul Medipol University Affiliated: Yes


Background and aims: The aim of this study was to evaluate the glycemic parameters, lipid profiles, uric acid levels, and triglyceride-glucose (TyG) index of individuals who consume different amounts of fructose. Additionally, the relationship between the TyG index and the homeostatic model assessment for insulin resistance (HOMA-IR) values was investigated. Methods: This cross-sectional study was conducted on healthy adults aged between 18 and 55 who applied to a university hospital in Istanbul, Turkey. Demographic characteristics and food consumption were recorded using the face-to-face interview method. Participants were divided into two groups according to their fructose consumption (≤50 g/day: moderate; >50 g/day: high). The glycemic parameters, lipid profiles, and uric acid levels were measured and TyG index was calculated. Results: Fructose consumption of >50 g/day was reported by 25% of the participants. There was no relationship between lipid profile, uric acid, and fructose consumption. The fasting blood glucose (FBG), fasting insulin, HOMA-IR, and TyG index values in the moderate fructose consumption group were significantly lower than those for the high fructose consumption group (P < 0.05). The TyG index was associated with fructose consumption and HOMA-IR (P < 0.05). High fructose consumers exhibited FBG and HOMA-IR levels 1.18 (95% confidence interval [95% CI] = 1.01–1.37) and 1.42 (95% CI = 1.09–1.84) times higher than those for the moderate fructose consumers (P < 0.05). Conclusions: The results of this study confirmed that high fructose consumption negatively affects glycemic status in healthy adults. Additionally, this study revealed that there is a significant association between daily fructose consumption and TyG index.