Synthesis, structural elucidation and pharmacological properties of some 5-acetyl-3,4-dihydro-6-methyl-4-(substituted phenyl)-2(1H)-pyrimidinones

Yarim M., SARAÇ S., Ertan M., Batu Ö., Erol K.

Farmaco, cilt.54, sa.6, ss.359-363, 1999 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 54 Sayı: 6
  • Basım Tarihi: 1999
  • Doi Numarası: 10.1016/s0014-827x(99)00042-7
  • Dergi Adı: Farmaco
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.359-363
  • Anahtar Kelimeler: tetrahydropyrimidine-2-ones, synthesis, UV, IR, H-1 and C-13 NMR, and mass spectra, calcium antagonistic activity
  • İstanbul Medipol Üniversitesi Adresli: Hayır

Özet

In this study, the synthesis of some new 5-acetyl-3,4-dihydro-6-methyl-4-(substituted phenyl)-2(1H)-pyrimidimones has been reported. The compounds were prepared by the Biginelli reaction of acetylacetone with aromatic aldehydes and urea. The structures of the compounds were characterized by UV, IR, 1H NMR, 13C NMR, mass spectra and elementary analysis. The calcium antagonistic activity of these compounds was tested in vitro on rat ileum precontracted with 4 x 10-3 M barium chloride.