Supplementation of docosahexaenoic acid (DHA) / Eicosapentaenoic acid (EPA) in a ratio of 1/1.3 during the last trimester of pregnancy results in EPA accumulation in cord blood
Prostaglandins Leukotrienes and Essential Fatty Acids, cilt.125, ss.32-36, 2017 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 125
- Basım Tarihi: 2017
- Doi Numarası: 10.1016/j.plefa.2017.08.005
- Dergi Adı: Prostaglandins Leukotrienes and Essential Fatty Acids
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.32-36
- Anahtar Kelimeler: Docosahexaenoic acid (DHA), Eicosapentaenoic acid (EPA), Omega-3 fatty acids, Omega supplement, Pregnancy, Umbilical cord
- İstanbul Medipol Üniversitesi Adresli: Evet
Özet
Omega-3 fatty acids (n-3 FA), specifically DHA, are associated with fetal growth and development. We aimed to determine the levels of DHA and EPA in cord serum after n-3 FA supplementation during the last trimester of pregnancy. Among 55 women, 23 were administered daily one capsule of n-3 FA supplement, involving DHA/EPA in a ratio of 1/1.3. Twenty nine women were enrolled as control group. Blood samples were collected at 22–24 weeks of gestation and at delivery. Fatty acids were analyzed with the method of GC-MS. Cord DHA level increased and EPA level decreased in both groups between the days of 22–24 and delivery. However, decrease in cord EPA level was significant in control group (p < 0.001) but not in supplement group (p > 0.05). Supplementation of DHA/EPA in a ratio of 1/1.3 during the last trimester of pregnancy caused higher cord EPA level compared to control group indicating an accumulation in umbilical cord.